排列5中三个多少钱:B7 Family Protein

Part of Featured B7 Family Proteins

Catalogue Product name Purity Endotoxin
13482-H02H Human B7-H5 / Gi24 / VISTA Protein (ECD, Fc Tag) > 95 % as determined by SDS-PAGE < 1.0 EU/μg protein
10084-H02H Human PD-L1 / B7-H1 / CD274 Protein (Fc Tag) > 95 % as determined by SDS-PAGE < 1.0 EU/μg protein
11188-H08H Human B7-H3 / CD276 Protein (His Tag) > 98 % as determined by SDS-PAGE < 1.0 EU/μg protein
11524-H02H Human CD28 Protein (Fc Tag) > 90 % as determined by SDS-PAGE < 1.0 EU/μg protein
10698-H08H Human CD80 / B7-1 Protein (His Tag) > 95 % as determined by SDS-PAGE < 1.0 EU/μg protein
80381-R02H Rat ICOS / AILIM / CD278 Protein (Fc Tag) > 95 % as determined by SDS-PAGE < 1.0 EU/μg protein
10738-H08H Human B7-H4 / B7S1 / B7x Protein (His Tag) > 95 % as determined by SDS-PAGE < 1.0 EU/μg protein
50017-MCCH Mouse B7-H4 / B7S1 / B7x / VTCN1 Protein > 90 % as determined by SDS-PAGE < 1.0 EU/μg protein
50124-M08H Mouse PD1 / PDCD1 Protein (His Tag) > 95 % as determined by SDS-PAGE < 1.0 EU/μg protein
50466-M02H Mouse ICOS / AILIM / CD278 Protein (Fc Tag) > 97 % as determined by SDS-PAGE < 1.0 EU/μg protein
50503-M02H Mouse CTLA4 / CD152 Protein (Fc Tag) > 95 % as determined by SDS-PAGE < 1.0 EU/μg protein
50446-M02H Mouse CD80 / B7-1 Protein (Fc Tag) > 90 % as determined by SDS-PAGE < 1.0 EU/μg protein

Background of B7 family protein

12097期排列5 www.ixpcv.com The B7 family, belonging to surface glycoproteins, contains immunoglobulin-like domains. B7 family consists of ten known members, which are B7.1 (CD80), B7.2 (CD86), B7-DC (PD-L2), B7-H1 (PD-L1), B7-H2 (ICOSLG), B7-H3 (CD276), B7-H4 (VTCN1), B7-H5 (VISTA), B7-H6 (NCR3LG1) and B7-H7 (HHLA2). The last three members are recently identified. B7 family molecules have the co-stimulation or co-inhibition capability. B7 family members bind to the CD28 family members primarily, such as CD28, CTLA-4, PD-1 and ICOS. B7-H1 has two co-inhibition receptors and B7-H2 has two co-stimulation receptors. The receptors of B7-H3 and B7-H4 have not been identified. B7 family members play important role in maintaining self-tolerance and regulating innate and adaptive immunity in tumor hosts. As an important immunotherapeutic method, B7 family is being studied for the treatment of cancer in humans currently.